BPC-157
Research Overview · Mechanism of Action · Reconstitution Guide
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide (15 amino acids: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice protein BPC. It is stable in gastric acid and has been extensively studied in rodent models for its effects on tissue repair, angiogenesis, and gastrointestinal protection. BPC-157 has no known endogenous receptor but modulates multiple growth factor pathways.
Mechanism of Action
BPC-157 upregulates VEGF expression and promotes angiogenesis through nitric oxide (NO) pathway modulation. It activates FAK-paxillin signaling to accelerate fibroblast migration and tendon cell outgrowth. In gastrointestinal models, it protects against NSAID-induced lesions by maintaining mucosal integrity and modulating prostaglandin synthesis. BPC-157 also interacts with the dopaminergic and serotonergic systems in CNS models. Its cytoprotective effects appear to be mediated partly through upregulation of the growth hormone receptor and EGR-1 transcription factor.
Key Studies & References
Sikiric P et al. (2018). Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract. Current Pharmaceutical Design 24:1604–1632.
Chang CH et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol 110:774–780.
Gwyer D et al. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res 377:153–159.
Bacteriostatic Water Reconstitution Guide
Research Use Only — The following reconstitution information is provided for in vitro laboratory research purposes only. Not for human or veterinary use.
Recommended Solvent
Bacteriostatic water (0.9% benzyl alcohol)
Standard Volume
Add 2 mL bacteriostatic water to a 5 mg vial to yield a 2500 mcg/mL solution. For a 500 mcg/mL working solution, add 10 mL.
Working Concentration
Common working concentrations: 500 mcg/mL or 1000 mcg/mL.
Storage (Reconstituted)
Reconstituted: 2–8°C, use within 28 days. Lyophilized: -20°C, desiccated.
Stability Window
Stable for 28 days refrigerated. BPC-157 is relatively stable in solution compared to many peptides.
Technique
Inject bacteriostatic water slowly along the vial wall. Gently swirl until dissolved. BPC-157 dissolves readily — solution should be clear within 60 seconds.
Notes
BPC-157 is one of the more stable peptides in solution. Bacteriostatic water is strongly preferred over sterile water for extended research use.
Research Dosing Reference
The following dosing information is derived from published preclinical research literature and is provided for reference purposes only.
Clinical / Human Research Range
No approved clinical dosing. Human trials have used 10 mcg/kg oral and parenteral routes.
Preclinical Models
Rodent studies: 10 mcg/kg to 10 mg/kg, subcutaneous or intraperitoneal. Most published studies use 10 mcg/kg as the effective dose in rats.
Calculation Example
For a 500 mcg/mL solution: a 250 mcg research dose = 0.5 mL. Use an insulin syringe (0.5 mL / 50 unit) for precision dosing.