Selank
Research Overview · Mechanism of Action · Reconstitution Guide
Overview
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg). The Pro-Gly-Pro extension, identical to that in Semax, confers metabolic stability. Developed at the Institute of Molecular Genetics in Russia, Selank has been approved in Russia as an anxiolytic and nootropic agent. It is studied for its GABAergic modulation, enkephalinase inhibition, and cytokine-regulatory properties.
Mechanism of Action
Selank modulates GABAergic neurotransmission, producing anxiolytic effects without the sedation or dependence associated with benzodiazepines. It inhibits enkephalin-degrading enzymes (enkephalinase), prolonging endogenous opioid peptide activity and contributing to anxiolytic and mood-stabilizing effects. Selank also regulates IL-6 expression and T-helper cell balance, linking its anxiolytic and immunomodulatory properties. In memory models, it enhances consolidation and retrieval, possibly through BDNF upregulation and cholinergic pathway modulation.
Key Studies & References
Semenova TP et al. (2010). Selank and semax affect the behavior and brain monoamine levels in rats with different phenotypes of emotional-stress reactivity. Zh Vyssh Nerv Deiat Im I P Pavlova 60:456–463.
Zozulya AA et al. (2001). Antiamnesic effect of selank. Bull Exp Biol Med 131:273–275.
Uchakina ON et al. (2008). Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova 108:71–75.
Bacteriostatic Water Reconstitution Guide
Research Use Only — The following reconstitution information is provided for in vitro laboratory research purposes only. Not for human or veterinary use.
Recommended Solvent
Bacteriostatic water (0.9% benzyl alcohol) or sterile saline
Standard Volume
Add 1 mL bacteriostatic water to a 1 mg vial to yield a 1000 mcg/mL solution.
Working Concentration
1000 mcg/mL standard working concentration.
Storage (Reconstituted)
Reconstituted: 2–8°C, use within 28 days. Lyophilized: -20°C, desiccated.
Stability Window
28 days refrigerated. Stable in solution.
Technique
Inject solvent slowly. Swirl gently until dissolved. Clear, colorless solution expected.
Notes
Like Semax, Selank is also studied via intranasal administration. For intranasal research protocols, sterile saline is the preferred vehicle.
Research Dosing Reference
The following dosing information is derived from published preclinical research literature and is provided for reference purposes only.
Clinical / Human Research Range
Russian clinical use: 400 mcg intranasal (200 mcg per nostril), 2–3 times daily.
Preclinical Models
Rodent studies: 100–300 mcg/kg subcutaneous or intranasal.
Calculation Example
For a 1000 mcg/mL solution: a 250 mcg research dose = 0.25 mL (25 units on a 100-unit insulin syringe).